Tiêu đề 12- MCQ Endocrine System.pdf ✅

The Genius in Biochemistry Endocrine System Dr. Mohamed Agha Endocrine System 1. Concerning Insulin Receptor and IRS a- Each Beta chain acts as Tyrosine kinase and phosphorylates the other Beta chain. b- IRS binds to the phosphorylated alpha chain of insulin receptor. c- Beta subunit of the receptor binds insulin d- IRS protein phosphorylates insulin receptor 2. Vitamin D promotes Ca uptake from intestine by: a- Binding to Ca and transporting it across cell membrane b- Activating genes that increase synthesis of Calbindin-D c- Decreasing mobilization of Ca from intestine to blood d- Enhancing activity of PTH which facilitates Ca transport in intestine 3. All the following describe insulin correctly Except: a- Pro-insulin is converted to insulin following secretion from beta cells b- It is polypeptide composed of 2 chains of amino acids connected by Disulphide bridges c- The 2nd messenger is tyrosine kinase phosphorylation cascade d- It is Group IId hormone 4. The major difference between hormones that have intra cellular receptor and those that have cell membrane receptor is that the former tend to be: a- Charged b- Amino Acid derivatives c- Hydrophobic d- Proteins 5. Mechanism of Glucagon action involves all the following except: a- Activation of Protein Kinase C b- Interaction with trans membrane segment receptor c- Activation of phosphorylase kinase and inhibition of glycogen synthase d- Activation of a Gs hetero trimeric protein

The Genius in Biochemistry Endocrine System Dr. Mohamed Agha 12. 2 nd messenger in Group II a is: a- cAMP b- cGMP c- Ca d- Tyrosine Kinase 13. 2 nd messenger in group II c is: a- cAMP b- cGMP c- Ca d- Tyrosine kinase 14. All the following are Group II a except: a- Epinephrine b- Glucagon c- PTH d- ADH 15. All of the following are Cortisol actions EXCEPT: a- Increases Blood Glucose b- Demineralization of bone c- Increases PEPCK transcription in Liver d- Activates Osteoblasts 16. Insulin Disulphide bonds are all the following Except: a- A7 to B7 b- A6 to A11 c- A20 to B19 d- A19 to B20 17. Metabolic action of Insulin is due to activation of: a- IRS-1 b- IRS-2 c- MAP Kinase d- None of the Above