Tiêu đề FINALS-POST LABORATORY DISCUSSION IN MEDCHEM.pdf ✅

PREPARED BY: RACHEL M. ORDOÑEZ, RPh ULS PHARMACY DEPARTMENT-CLINICAL INSTRUCTOR SYNTHESIS OF ASPIRIN POST-LABORATORY DISCUSSION NO. 1 FOR FINALS
ASPIRIN • Chemical name: acetyl salicylic acid (ASA) • IUPAC name: 2-acetobenzoic acid • Was first synthesized in 1893 by Felix Hoffmann, a chemist from the German firm of Bayer. PREPARED BY: RACHEL M. ORDOÑEZ, RPh ULS PHARMACY DEPARTMENT-CLINICAL INSTRUCTOR
ASPIRIN • It is both an organic ester and an organic acid. • It is used extensively in medicine as a pain killer and as a fever reducing drug. • Have anti-inflammatory and anti-thrombotic activity as well. • It is prepared by reacting salicylic acid with acetic anhydride. PREPARED BY: RACHEL M. ORDOÑEZ, RPh ULS PHARMACY DEPARTMENT-CLINICAL INSTRUCTOR
ASPIRIN • Melting point: 136 °C (277 °F) • Boiling point: 140 °C (284 °F) • Qualitatively, the purity of aspirin sample can be determined from its melting point. The melting point of a substance is essentially independent of atmospheric pressure, but is always lowered by the presence of impurities (the degree of lowering of melting point depends on the nature and the concentration of the impurities). PREPARED BY: RACHEL M. ORDOÑEZ, RPh ULS PHARMACY DEPARTMENT-CLINICAL INSTRUCTOR