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PT - PHYSIO Chapters 1 to 10 - Guyton & Hall Signal Transduction - Boron Boron 3rd ed p53 11 Intracellular = 300 mOsm/kg (nonpermeant) and Extracellular = 320 mOsm/kg (nonpermeant) What is the osmolality and tonicity? Hyperosmolar, Hypertonic 12 When skeletal muscle contracts: I band and H band shortens while A band remains unchanged 13 The physician accidentally performed IV infusion of 300 mOsm of urea solution. After 30 minutes, lab results showed RBCs had swollen. What should you do to prevent the cause? Add NaCl to make it isotonic Although the infused urea solution had an osmolarity of 300 mOsm/L, making it isosmotic with plasma, it was not isotonic to red blood cells (RBCs) Mechanism of RBC Swelling: 1. Urea is a penetrating solute — it can freely diffuse across the RBC membrane. 2. When urea enters the RBCs, the intracellular

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