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رارعة الق س ن ؤ م 1 | P a g e 1) The introduction of which of the following substituents into the lead compound would increase its lipophilicity? A. Carboxylic acid substituent B. Amine substituent C. Hydroxy substituent D. Halogen substituent such as chlorine, bromine and iodide. 2) If medicines are administrated locally, a higher concentration of the medicine can reach the site of action? A. Yes B. No 3) Usually, only highly lipid-soluble medicines can cross the blood brain barrier and penetrate into the central nervous system? A. True B. False 4) Which of the following statements is true regarding a tertiary amide? A. It can only participate in hydrogen bonding as a hydrogen bond donor B. It cannot participate in hydrogen bonding at all C. It can participate in hydrogen bonding both as a hydrogen bond donor and hydrogen bond acceptor D. It can only participate in hydrogen bonding as a hydrogen bond acceptor 5) Which of the factors below affect drug absorption? A. Drug lipid-water solubility B. Drug molecular weight C. Drug degree of ionization D. Area of absorptive surface E. All options given are correct
رارعة الق س ن ؤ م 2 | P a g e 6) Aqueous pores in gastrointestinal membrane: A. Are used by drugs that are too large to cross membranes by pinocytosis B. Are only used by lipid soluble drugs C. Transport most drugs across membranes D. Allow very small, charged molecules or ions to cross membranes E. Are used to transport drug molecules that resemble certain amino acids or glucose. 7) Most acidic drugs (pKa > 2) are absorbed from: A. Intestine B. Stomach and intestine C. They cannot be absorbed D. Stomach 8) Most basic drugs (pKa < 8) are absorbed from: A. Intestine B. Stomach and intestine C. They cannot be absorbed D. Stomach 9) Which type of drugs get absorbed by ion-pair transport process? A. Drugs that are positively ionized at all PH conditions B. High lipophilicity C. Weakly acidic drugs with pKa 8 D. Oily droplets 10) At low PH a weakly acid drug (pKa 5.5) absorption is expected to be: A. Less readily, because it is less ionized B. More readily, because it is more ionized C. More readily, because it is less ionized

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