Nội dung text Treatment of endometrial cancer molecular subtypes and treatment implications - Catagay.pdf
Treatment of Endometrial Cancer Molecular Subtypes and Treatment Implications Cagatay Taskiran, MD., Prof VKF Koc University School of Medicine, and American Hospital, Chair, Department of Gynecologic Oncology
Failure in the Treatment of Endometrial Cancer Endometrial Cancer (EC) remains the only gynecologic malignancy with a rising incidence and mortality While patients diagnosed at an early- staged (low-risk) have an excellent prognosis, those diagnosed at a late stage have a 5 year survival rate of only 17. Sung. H. et al. CA Cancer J. Clin, 2021; Colombo N et al. Ann Oncol,2016; Bestvina CM & Fleming GF. Oncologist,2016; Concin N. at al. Int J Gyn Cancer, 2021; Yang S et al. Discov Med, 2011; Fleming GF, et al. J Clin Oncol,2004; O’ Malley DM, et al. J Clin Oncol, 2022; Miller DS, et al. Gynecol Oncol, 2012; Miller DS, et al., J Clin Oncol, 2020
GOG0209: PFS & OS
Big Revolution in 2013 & The Cancer Genom Atlas
TCGA - 2013 G Getz et al. Nature 497, 67-73 (2013) doi:10.1038/nature12113 POLEmut MMRd pMMR p53abn
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