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Diabetes mellitus
• When to start: • A1C at or above target level (ie, >7.5 to 8 percent), metformin should be initiated at the time of diabetes diagnosis. • A1C near target (ie, <7.5 percent), a three- to six-month trial of lifestyle modification before initiating pharmacologic therapy is reasonable. • For patients presenting with A1C >9.5, insulin remains the preferred initial therapy. T2DM management
• Metformin monotherapy failure: • Insulin is the preferred second-line medication for patients with A1C >8.5 percent despite initial therapy with metformin and lifestyle intervention. • For those close to A1C target (>8.5 percent), we prefer to add a sulfonylurea rather than insulin. T2DM management