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PHARMD GURU Page 3 SERUM PROTEINS: Primary serum proteins measured are albumin and the globulins (i.e.α, β, γ ) Albumin (4 to 6 g/dL) maintains serum oncotic pressure and serves as a transport agent. Because it is primarily manufactured by the liver, liver disease can decrease albumin levels. Albumin can also be used to assess nutritional status. Globulin (23 to 35 g/L) relates to the total measurement of immunoglobins (antibodies) found in the serum and function as transport agents and play a role in certain immunological mechanisms. A decrease in albumin levels usually results in a compensatory increase in globulin production. Normal values for total serum protein levels are 6 to 8 g/dL (60 to 80 g/L).