Tiêu đề 3 Placental Drug Transfer.pdf ✅

PLACENTAL DRUG TRANSFER TYPES : L - > Complete transfer Exceedingtransfer Incomplete transfer (typel) (type2) (type3) Rapidly cross the Gossplacenta Unableto cross the placenta placenta - Physiologically significant concentration Greater come in Greater come in - Equilibrating in fetal blood , maternal blood Maternal-Fetal as comparedto maternal blood blood . Eg : Thiopental Eg : Ketamine Eg : Scaline MECHANISMS Drugs which transfer to fetal blood from maternal blood , are carried into Intervillous - Space , - connective pass throughSyncytiotrophoblast , fela tissue , and endothelium of fetal capillaries of Sycytiotrophoblastcells covering the Villi.

I SIMPLE DIFFUSION · Mostly type I drugs · Transfer : a) transcellularly through Syncytiotrophoblast or b) paracellularly through water - channels , incorporated into the membrane . · Energy not required (PASSIVE) · dependant on Concentration gradient , across the placenta with drug passively moving · from areas of HIGH to Low Concentration. FICK's Law of Diffusion L /t = &A (Cm-Cf) Q/t : Rate ofdiffusion D k: Diffusion Coefficient A : Surface area of membrane Cm : Maternal Concentration Cf : Fetal concentration D : Thickness of membrane * Total drug dase = Material X Fetal to Maternal to infant Concentration ratio of drug Umbilical vein Maternal vein