Tiêu đề 2-lektsiya-Klinichna-imunologia-studenti-Medicine-EN-2019-2020-II.pdf ✅

Immunopathology. Immunodeficiencies. Prof. Marianna Murdjeva, MD, PhD Department of Microbiology and Immunology, Medical University - Plovdiv Immunopathology Unadequate Unadequate immune reactions immune reactions leading to disease conditions: leading to disease conditions:  Immunodeficiencies Immunodeficiencies  Allergy Allergy  Autoimmune diseases Autoimmune diseases  Infectious diseases of immune system Infectious diseases of immune system  Post-transplantation reactions transplantation reactions  Tumor immunology Tumor immunology  Reproductive disorders Reproductive disorders
IMMUNODEFICIENCIES (inability of the immune system to react properly)  1. Primary- heterogeneous group of inherited, genetic disorders of the immune system (usually autosomal- recessive)  2. Secondary (acquired). Factors leading to Sec ID: acquired). Factors leading to Sec ID:  Infections (bacterial, viral, protosoal)  Tumors of the immune system  Immunsuppressive and anti-microbial therapy  Burns and severe surgical trauma  Metabolic disorders
PRIMARY ID (PID) > 200 types Frequency – low - In USA – about 500 000 cases - Each year – 50 000 new cases - 1:10 000 newborns in Western Europe and North America suffer from PID Infections Infections - the most common the most common symptom of PID symptom of PID Other signs:  Autoimmune diseases  Gastrointestinal disorders  Malignant processes