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Prolactin Physiology Basics  Produced by lactotroph cells in the anterior pituitary  Secretion is tonically inhibited by dopamine from the hypothalamus  Stimulated by estrogen, TRH, and stress-induced factors (like cortisol) Normal Ranges  Men: < 15 ng/mL  Women (non-pregnant): < 20 ng/mL Mechanisms of Action: How Natural Agents Work Compound Mechanism Mucuna Pruriens Increases dopamine via L-DOPA → dopamine inhibits prolactin Vitamin B6 (P5P) Cofactor in dopamine synthesis → supports dopaminergic tone Zinc Modulates dopamine receptors + inhibits pituitary prolactin secretion Adaptogens (Ashwagandha, Rhodiola) Lower cortisol → reduces stress-induced prolactin rise Estrogen Management Reducing estrogen reduces indirect prolactin stimulation Dosages & Timing Supplement Dose Timing Notes Mucuna Pruriens 300–500 mg/day Morning (empty stomach) Standardized to 15% L- DOPA Vitamin B6 (P5P) 50–100 mg/day With food, split AM/PM Avoid neurotoxicity at high doses Zinc Picolinate 30–50 mg/day (elemental) With meals Avoid with calcium Ashwagandha (KSM- 66) 600 mg/day Before bed Enhances sleep, lowers cortisol Rhodiola Rosea 200–400 mg/day AM (empty stomach) Avoid late dosing (stimulating) Get My Recommended Supplements Right Here
Cycling or Pulsing  Mucuna: 5 days on / 2 days off to prevent dopamine receptor downregulation  Adaptogens: Rotate monthly or take 1 week off every 4–6 weeks Monitoring Markers  Blood test: Serum Prolactin  Track symptoms: libido, mood, sexual function Benefits & Outcomes Short-Term Benefits  Improved mood and motivation  Increased libido  Better energy and sleep Long-Term Benefits  Restored HPTA balance (Testosterone–LH–FSH)  Reduced risk of prolactin-induced gynecomastia  Greater performance output via dopamine optimization Unexpected Bonuses  Better sperm parameters (via zinc and B6)  Elevated drive and goal-seeking behavior (dopamine-driven) Side Effects, Risks, and Safety Compound Potential Side Effects Prevention Strategy Mucuna Overstimulation, insomnia Cycle it, avoid late dosing B6 (high doses) Neuropathy at >200 mg/day over long term Stay under 100 mg/day Zinc (excessive) Copper depletion, GI upset Add copper 2 mg if long-term use Adaptogens Can blunt stress response if abused Pulse usage periodically

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