Tiêu đề Chapter 6_Molecular Basis of Inheritance.pdf ✅

UNIT VII : GENETICS AND EVOLUTION Note: Directions for Assertion & Reason Questions (A) If both Assertion & Reason are True & the Reason is a correct explanation of the Assertion (B) If both Assertion & Reason are True but Reason is not a correct explanation of the Assertion. (C) If Assertion is True but the Reason is False (D) If both Assertion & Reason are False Chapter 6 : Molecular Basis of Inheritance 1. DNA finger printing profile will be exactly same of (a) Sibling (b) Monozygotic twins (c) Offsprings (d) Dizygotic twins (1) a and b only (2) b and c only (3) b only (4) b and d only 2. Which one is incorrect for variable number of tendom repeats (VNTR)? (1) It is a location in a genome where short nucleotide sequence is organised as tendom repeat. (2) The number of repeat varies from chromosome to chromosome in an individual and also between individuals. (3) Its size varies from 0.1 to 20 kbp. (4) It is exactly same in dizygotic twins. 3. In gel electrophoresis :- (1) DNA fragments are arranged according to length on gel by applying electric field (2) DNA fragments are arranged according to charge (3) DNA fragments are treated by alkali solution (4) DNA fragments are denatured 4. An analysis of chromosomal DNA using the Southern hybridization technique does not use :- (1) Electrophoresis (2) Blotting (3) Autoradiography (4) PCR 5. Main basis of DNA finger printing is :- (1) RFLP (2) VNTR (3) RAPD (4) None of these 6. Find an incorrect statement with respect to findings of HGP :- (1) Dystrophin protein gene is largest gene of human genome (2) Chromosome-Y has minimum 231 genes (3) SNP's were identified at about 2.4 million locations. (4) The functions are unknown for over 50% of discovered genes. 7. HGP in closely associated with the rapid development of a new area in biology, called as:- (1) Biotechnology (2) Bioinformatics (3) Bioscience (4) Biogeography 8. Which of the following is necessary for DNA finger printing ? (1) Restriction digestion (2) Southern blotting (3) Autoradiography (4) All of the above 9. HGP methodology which includes identification of all the genes that expressed as RNA is referred as- (1) Sequence Annotation (2) EST (3) RFLP (4) ELSI 10. Select the incorrect statement regarding VNTR :- (1) It is composed of mini satellite DNA (2) Its size in human being varies from 0.1 to 20 kb (3) It shows high degree of polymorphism (4) It does not differ from individual to individual in a population
11. Which of the following tools of recombinant DNA technology is incorrectly paired with it's use ? (1) Restriction endo nuclease-Production of DNA Fragment for gene cloning (2) DNA ligase - enzyme that acts on DNA, creating sticky end (3) DNA polymerase - copies DNA sequence in the polymerase chain reaction (4) Reverse transcriptase - production of c DNA from m RNA 12. Frederick sanger is associated with (1) Developing method for determination of amino acid sequence (2) Developing method for biochemical analysis of macromolecule (3) Artificial gene (4) Formation of cloning vector 13. Select the incorrect statement. (1) DNA from single cell is enough to perform DNA fingerprinting analysis (2) DNA fingerprinting has much wider applications in determining population & genetic diversities (3) The VNTR belongs to a class of non repetitive DNA (4) DNA fingerprint differs from individual to individual in a population except in the case of monozygotic twins 14. Select the incorrect statement for RFLP :- (1) It is the basis of DNA fingerprinting. (2) It is due variable length of restricted fragments. (3) It is due to variable number of mini satellites. (4) It is same for all human beings. 15. Select the correct match with respect to findings of HGP. (1) Largest gene → 2400 bp. (2) Smallest gene → Holandric chromosome (3) EST → 1.4 million locations (4) Chromosome-1 → Largest gene 16. Which suspect would you charge with the crime? (1) Both suspect 1 & 2 (2) Only suspect 1 (3) Only suspect 2 (4) Neither suspect 1 nor suspect 2 17. DNA fingerprinting is based on the principle of (1) Double helical structure of DNA (2) Coding sequence are identical in all individuals. (3) Polymorphism in non-coding sequences (4) Semi-conservative mode of replication 18. Assertion :- The functions are unknown for over 50% of discovered gene in HGP. Reason :- Less than 2% of the human genome codes for protein. (1) A (2) B (3) C (4) D 19. How are RFLPs detected :- (1) By amplifying the DNA using PCR (2) By doing standard mendelian cross (3) By observing DNA of different lengths on a Nitrocellulose membrane.
(4) By obserbing the chromosome under microscope KEY 1) 3 2) 4 3) 1 4) 4 5) 1 6) 3 7) 2 8) 4 9) 2 10) 4 11) 2 12) 1 13) 3 14) 4 15) 2 16) 4 17) 3 18) 2 19) 3 20) NEET/AIPMT PREVIOUS QUESTIONS 1. Frequency of an allele in an isolated population may change due to: 1) Genetic drift 2) Gene flow 3) Mutation 4) Natural selection 2. DNA fingerprinting refers to : 1) Analysis of DNA samples using imprinting devices 2) Techniques used for molecular analysis of different specimens of DNA 3) Techniques used for identification of fingerprints of individuals 4) Molecular analysis of profiles of DNA Samples 3. Satellite DNA is useful tool in: 1) organ transplantation 2) sex determination 3) Forensic science 4) genetic engineering 4. Commonly used vectors for human genome sequencing are: 1) T-DNA 2) BAC and YAC 3) Expression Vectors 4) T/A Cloning Vectors 5. An abnormal human baby with ‘XXX’ sex chromosomes was born due to: 1)fusion of two sperms and one ovum 2) formation of abnormal sperms in the father 3) formation of abnormal ova in the mother 4) fusion of two ova and one sperm 6. Multiple alleles are present: 1) On non-sister chromatids 2) On different chromosomes 3) At different loci on the same chromosome 4) At the same locus of the chromosome 7. A man with blood group A’ marries a woman with blood group B’. what are all the possible blood groups of their offspring? 1) O only 2) A and B only 3) A, B and AB only 4) A, B , AB and O 8. A gene showing codominance has : 1) both alleles independently expressed in the heterozygote 2) one allele dominant on the other 3) alleles tightly linked on the same chromosome 4) alleles that are recessive to each other 9. Satellite DNA is important because it: 1) codes for enzymes needed for DNA replication 2) codes for proteins needed in cell cycle 3) shows high degree of polymorphism in population and also the same degree of