Nội dung text Medical Microbiology and Immunology Warren Levinson (Al HaYaT).pdf
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McGraw-Hill Education books are available at special quantity discounts to use as premiums and sales promotions, or for use in corporate training programs. To contact a representative, please visit the Contact Us pages at www.mhprofessional.com. Review of Medical Microbiology and Immunology, Fourteenth Edition Copyright © 2016 by McGraw-Hill Education. All rights reserved. Printed in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher. Previous editions copyright © 2014, 2012, 2010, 2008, 2006, 2004, 2002, 2000 by The McGraw-Hill Companies, Inc., and copyright © 1998, 1996, 1994, 1992, 1989 by Appleton & Lange. 1 2 3 4 5 6 7 8 9 0 DOW/DOW 19 18 17 16 ISBN 978-0-07-184574-8 MHID 0-07-184574-7 ISSN 1042-8070 Notice Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibil- ity of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. This book was set in Minion pro by Cenveo® Publisher Services. The editors were Michael Weitz and Brian Kearns. The production supervisor was Richard Ruzycka. Project management was provided by Tanya Punj, Cenveo Publisher Services. The designer was Elise Lansdon. Cover photo: colorized electron micrograph of swine influenza virus; credit: Science Source. RR Donnelley was the printer and binder. This book is printed on acid-free paper. International Edition ISBN 978-1-259-25127-6; MHID 1-259-25127-6. Copyright © 2016. Exclusive rights by McGraw-Hill Education for manufacture and export. This book cannot be re-exported from the country to which it is consigned by McGraw-Hill Education. The International Edition is not available in North America. mebooksfree.com
Contents Preface v Acknowledgments vii How to Use This Book ix iii PA RT I BASIC BACTERIOLOGY 1 1. Bacteria Compared with Other Microorganisms 1 2. Structure of Bacterial Cells 4 3. Growth 15 4. Genetics 18 5. Classification of Medically Important Bacteria 24 6. Normal Flora 26 7. Pathogenesis 31 8. Host Defenses 52 9. Laboratory Diagnosis 61 10. Antimicrobial Drugs: Mechanism of Action 69 11. Antimicrobial Drugs: Resistance 87 12. Bacterial Vaccines 96 13. Sterilization & Disinfection 100 PA RT II CLINICAL BACTERIOLOGY 105 14. Overview of the Major Pathogens & Introduction to Anaerobic Bacteria 105 15. Gram-Positive Cocci 109 16. Gram-Negative Cocci 128 17. Gram-Positive Rods 135 18. Gram-Negative Rods Related to the Enteric Tract 148 19. Gram-Negative Rods Related to the Respiratory Tract 171 20. Gram-Negative Rods Related to Animal Sources (Zoonotic Organisms) 177 21. Mycobacteria 183 22. Actinomycetes 194 23. Mycoplasmas 197 24. Spirochetes 199 25. Chlamydiae 208 26. Rickettsiae 212 27. Minor Bacterial Pathogens 217 PA RT III BASIC VIROLOGY 225 28. Structure 226 29. Replication 232 30. Genetics & Gene Therapy 244 31. Classification of Medically Important Viruses 248 32. Pathogenesis 253 33. Host Defenses 260 34. Laboratory Diagnosis 266 35. Antiviral Drugs 269 36. Viral Vaccines 280 PA RT IV CLINICAL VIROLOGY 285 37. DNA Enveloped Viruses 288 38. DNA Nonenveloped Viruses 304 39. RNA Enveloped Viruses 311 40. RNA Nonenveloped Viruses 333 41. Hepatitis Viruses 342 42. Arboviruses 354 43. Tumor Viruses 361 44. Slow Viruses & Prions 372 45. Human Immunodeficiency Virus 378 46. Minor Viral Pathogens 391 mebooksfree.com