Title Biohacking Bible - A Neuropharmacology Encyclopedia ✅

Biohacking Bible A Neuropharmacology Encyclopedia by ryderlefeg and editors Revised by Meso aka Deya Rabbie Neuropharmacology, B.Sc. Last updated on 26-05-2024 Check out the GPT bot Biohacker (beta version). And don’t forget to check out r/prefrontal as well.
--------------------------------------- If you want to download or print, you can get it from Gumroad. If you want to donate and support me, my PayPal (paste your email in the message) and crypto addresses (most preferred) are: SOL: 516mqdwzZkerw1PT64X7PaKWT13hSrT6W2fGWjBpe4gh ERC-20: 0xDaa1cad37f4da58B841365d96d140eD949f56E49 BTC: bc1qjwsr82d8slz06hexzus2kw47r94xe3y38hh7wf LTC: ltc1qz6hkcwdh4us0nu6hzclkcgtvrsgjgpxmsc5j3j XMR: 48qYHKaDDGFExz4hSAiZTi8Z623y5ehiC8kDxLNWRWCGZRQc5Nuby1G5edDz9BskD7L9CYhZXytkY5ip8XZ6qy1w2LL6k3r --------------------------------------- This is an overview of various drugs ranging from antidepressants to psychedelics, and pharmacology/neuroscience. I mostly go over the substances that I think would be of most help to the hypodopaminergic phenotype of neuropsychiatric disorders (ie. anhedonia, depression/anxiety, PSSD, DPDR and ADHD). A lot of pharmacological and neuroscientific concepts are explained in sufficient detail. Poor focus, depression and demotivation are often attributed to low dopamine and norepinephrine but low acetylcholine activity can also contribute sometimes. Acetylcholine is needed to maintain sustained attention and lack of acetylcholine due to low dietary choline can contribute to ADHD symptoms so make sure you eat enough choline-rich food like eggs, or supplement with CDP-choline/alpha-GPC. MAOIs increase concentrations of both dopamine and norepinephrine which is why they are highly regarded. One of the main reasons behind hypodopaminergic symptoms such as anhedonia, social withdrawal, short attention span and sexual dysfunction is supersensitivity to serotonin or excessive serotonergic signaling. Serotonin acts as a counterbalance to dopamine in the brain for the most part (it’s brain region specific; cortical 5-HT2A increases dopamine release to the NAc; while hypothalamic 5-HT1A increases dopamine , β-endorphin, oxytocin there), so one of the best ways to go around this is to block specific serotonin receptors. --------------------------------------- NOTE: none of this is medical advice. These are mainly my notes I’ve written after years of research. Some of the stuff mentioned in this ebook are experimental and are marked as such. It is NOT advisable to dabble with nootropics until you first adopt a healthy lifestyle by getting your gut, immune system, blood levels, hormones in the best shape possible, and adopt a healthy diet (including drinking filtered water).
Remember to also get thyroid and blood panels done. Ideally test for all vitamins, minerals and hormones but if you can’t get your doctor to refer you for those tests, then get lab tests done yourself at a Spectracell lab or order an Idealabs kit (easiest and cheapest method). You can also stack hepatoprotectors like black seed oil, NAC, TUDCA, Na-R-ALA/R-ALA, curcumin (with bioperine ideally), schisandra and/or milk thistle to reduce burden on the liver and protect from any hepatotoxic chemicals (including in your food). Safety note - never take TUDCA before alcohol as the combo is very toxic to the liver; and never take NAC after alcohol as the combo is, once again, toxic. This ebook is constantly updated so feel free to check it every once in a while (ie. once a month). And feel free to use the comment feature if you want to give feedback. If any link is down just use the archived mirror. It’s also highly recommended to get your genes tested by AncestryDNA (or Nebula Genomics deep sequencing with the “SAVE50” coupon if you can afford it); preferably from Amazon or a third-party for privacy before you dabble with nootropics. My ranking of DNA kits would be Nebula/Dante Labs/Sequencing.com > AncestryDNA > 23&Me. If you have MTHFR/COMT/MAOA/MTR/MTRR/VDR/BHMT/GNMT/CBS/ACAT gene mutations, make sure to insert your DNA data into Genetic Genie, Promethease or Strategene to get a detailed list of mutations, and respective supplements to counteract the effects of the mutations; and check out r/MTHFR for help. As an under-methylator or over-methylator, it’s recommended to get your methylation status in check before attempting to dabble with pharmaceuticals or nootropics. --------------------------------------- Scientifically Proven "Easy Testosterone-maxxing" Method Citation List ---------------------------------------
Cannabis-induced anhedonia requires a slightly different approach. Highly recommend BDNFan’s guide to recover from cannabis-induced anhedonia. --------------------------------------- Pharmaceuticals & Nootropics Antidepressants SSRIs These can be good for OCD, GAD and mild depression (rarely moderate or major). Fluvoxamine is the most effective out of all the SSRIs, but their use is not recommended as anything but a last-resort due to the risk of developing PSSD and also potential cognitive impairment. As for alternative herbal antidepressants, mesembrine takes the cake. MX-16 extract by UltraKanna is unmatched and is a vastly superior option compared to pharmaceutical antidepressants for most people. Most and not all because some would still find they get better responses to pharmaceuticals. Why Are SSRI Antidepressants So Harmful? SJW Ze 117/Perika is also another good alternative to SSRIs. Certain σ1 agonist SSRIs like fluoxetine and fluvoxamine increase neurosteroid production at microdoses, which can be nootropic. Fluvoxamine also inhibits weight gain which can be a plus for a lot of people. SSRIs used for OCD are sometimes dosed way higher than the recommended limit. For example, fluvoxamine can be dosed up to 450 mg/day for treatment-resistant OCD patients, while the recommended limit for depression is only 300 mg.