Title 19. PHARMACOLOGY OF IMMUNOSUPPRESSANTS AND STIMULANTS-converted.pdf ✅

PHARMD GURU Page 1 IMMUNO-STIMULANTS PHARMACOLOGY OF IMMUNOSUPPRESSANTS AND STIMULANTS
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PHARMD GURU Page 3 IMMUNOSUPPRESSANTS They are drugs that suppress the immune response; they inhibit cell- mediated/humoral immunity or both. Their main therapeutic application is in autoimmune diseases and organ transplantation. CLASSIFICATION: 1. Calcineurin inhibitors: Cyclosporine and tacrolimus 2. Antiproliferative and cytotoxic agents: Azathioprine, methotrexate, cyclophosphamide, mycophenolate mofetil 3. mTOR (mammalian target of rapamycin) inhibitor: Sirolimus, temsirolimus, everolimus 4. Glucocorticoids: Prednisolone, methylprednisolone 5. Biologics: a) TNF-a inhibitors: Etanercept, infliximab b) Interleukin (IL-1) inhibitors: Anakinra c) Antibodies: Muromonab-CD3, daclizumab, basiliximab, antithymocyte antibody and Rho (D) immunoglobulin. Details of some of the immunosuppressants are given in Table 12.2.
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