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NOTE TO INSTRUCTORS Contact your Elsevier Sales Representative for teaching resources, including slides and image banks, for Guyton and Hall Textbook of Medical Physiology, 14e, or request these supporting materials at: http://evolve.elsevier.com/Hall/physiology/
Guyton and Hall Textbook of Medical Physiology John E. Hall, PhD Arthur C. Guyton Professor and Chair Department of Physiology and Biophysics Director, Mississippi Center for Obesity Research University of Mississippi Medical Center Jackson, Mississippi Michael E. Hall, MD, MS Associate Professor Department of Medicine, Division of Cardiovascular Diseases Associate Vice Chair for Research Department of Physiology and Biophysics University of Mississippi Medical Center Jackson, Mississippi 1 4 T H EDITION
Elsevier 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103-2899 GUYTON AND HALL TEXTBOOK OF MEDICAL PHYSIOLOGY, FOURTEENTH EDITION ISBN: 978-0-323-59712-8 INTERNATIONAL EDITION ISBN: 978-0-323-67280-1 Copyright © 2021 by Elsevier, Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notice Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds or experiments described herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Previous editions copyrighted 2016, 2011, 2006, 2000, 1996, 1991, 1986, 1981, 1976, 1971, 1966, 1961, and 1956. Library of Congress Control Number: 2020936245 Publisher: Elyse O’Grady Senior Content Development Specialist: Jennifer Shreiner Publishing Services Manager: Julie Eddy Project Manager: Grace Onderlinde Design Direction: Margaret Reid Printed in Canada Last digit is the print number: 9 8 7 6 5 4 3 2 1

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