Title 10. BS. Hoàng Quang Minh.pdf ✅

Why Changed?  Challenges With AADs • Limited efficacy (40–60% rhythm control) • Significant side effects (e.g., amiodarone toxicity) • High recurrence rate after drug discontinuation • Do not halt atrial remodeling Marrouche NF et al., CASTLE-AF trial, NEJM 2018 Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure: Results From the CABANA Trial 2021