Title Yoyo Data Sheet colatage range L2.pdf ✅

Yoyo Data Sheet- Colatage Range L2 (Colatage plus / Colatage B) Colatage Plus 1. Physical Parameters 2. Pricing 3. Focused Speciality 4. Focused Indications 5. TGT Drs at P1 Speciality No of Drs Active Ingredients - Each Hard Gelation Capsule Contains Aflapin (Boswellia Serrata Extract) 100 mg + Native collagen Type II (4%) 40 mg + CurQlife (Curcuma Longa Extract) 100 mg + Mobilee (Sodium Hyaluronate, Polysaccharides & Collagen) 40 mg MRP - Rs 825.00 Ortho, CPs in OA Flare ups associated with restricted mobility and Synovitis Ortho, CPs 5 Primary Pack Size - Strip of 10 Caps in a mono carton PTR - Rs 559.32 Secondary Pack Size - 10 strips in 1 Box PTS - Rs 503.39 Tertiary Pack Size (shipper Qty) - 240 qty Shipper Cost - Rs 120813.6 Colour of the Capsule - Blue coloured hard gelatin capsule Benefit if Pricing, if any Flavour of the Capsule - None Technology of Brand - None Type of Pack - Alu Alu strip
6. Competition Details Brand Company Pack MRP Price/Unit COLLASHOT C2 INNOVCARE 10s 825.00 82.50 MOBIWALK SUNDYOTA 10s 799.00 79.90 CONJOINT 3D MEDLEY 10s 824.00 82.40 JOINTACE TRIO MEYER 10s 900.00 90.00 COLLAFLEX PRO PLUS UNIVERSAL 10s 1350.00 135.00 FITJOINT MAX EMCURE 10s 824.50 82.45 7. Key In clinic communication points A blend of 4 world class patented formulations for OA Flare ups associated with restricted mobility & Synovitis, Mobilee: oral Hyaluronic acid Mobilee, A patented natural ingredient with high concentration of Hyaluronic acid, increase intra-articular HA concentration 10 folds- Improves Mobility, reduces inflammation-improves range of motion, Reduces Joint discomfort-improves quality of life, increases muscular strength-improves working capacity CurQlife Contains three major types of curcuminoids, Curcumin, Demethoxy curcumin, Bisdemethoxy curcumin. prepared by using unique HLB technology. 48-fold higher bioavailability than standard curcuminoids. Superior & Sustained release of Curcuminoids: 80% Curcuminoid release at 30 minutes & 95% dissolutions within 1 hour Native collagen type II is an innovative form of Collagen peptide, Manufactured under patented low temperature non-enzymatic process. Biological active triple helix form in oral tolerization process to supress immune system Aflapin is a novel synergistic composition derived from Boswellia serrata. Has significantly better bioavailability then Boswellic extracts. More powerful anti-inflammatory efficacy and better recovery of Glycosaminoglycan in proinflammatory cytokine induced human chondrocyte TEC Advantage ... Step ahead in Technology, Step ahead in Efficacy, Step ahead in Compliance
Osteoarthritis: 1. Osteoarthritis is a degenerative joint disease, in which the tissues in the joint break down over time. 2. It is the most common type of arthritis and is more common in older people. 3. People with osteoarthritis usually have joint pain and, after rest or inactivity, stiffness for a short period of time. 4. An osteoarthritis flare-up is a sudden increase in symptoms. 5. The Treatment objective include 1. Symptomatic relief, 2. Retard the disease progression 3. Long-term safety of medication. Synovitis: When the synovium of a joint becomes inflamed (swollen). Hyaluronic acid in Joint: 1. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the body's connective tissue in skin, Joints. 2. Hyaluronic acid (HA) act as a lubricant to enable bones to move smoothly over each other and as a shock absorber for joint loads. 3. People with knee osteoarthritis have lower concentration and altered volume of hyaluronic acid than normal in their joints. (https://www.scirp.org/journal/papercitationdetails?paperid=85186&JournalID=2465) 4. This reduction of HA in osteoarthritic joints is a result of 1. Reduced Production & 2. Synovial Effusion 5. The Mainstay therapy include Visco supplementation along with Pain management. 6. The method of visco supplementation is 1. Intra articular injection 2. Increase endogenous production and 3. Reduce synovial effusion. Desired Results: 1. Reduce the Pain, inflammation & Joint Discomfort 2. Increase The muscle strength & Range of Motion 3. Increase the lubrication, Work capacity
Mobilee: 1. Mobilee is hyaluronic acid matrix ingredient extracted from rooster comb containing a high concentration of hyaluronic acid (60-75%) and other components, including polysaccharides (>10%) and collagen (>5%). 2. Tested in 11 clinical and pre-clinical studies, Mobilee® is shown to increase the endogenous synthesis of hyaluronic acid by synoviocites by 10-fold. 3. Mobilee Reduced inflammation by significantly lowering PGE2 levels in fibroblast cells. Furthermore it showed a tendency to lower MMP-1 levels (refer Image in VA Page) 4. After 3 months of consumption, the group taking Mobilee® had improved knee bending, reduced synovial fluid effusion, and less perceived pain in the affected knee, particularly over 50 years of age. (The studies were carried out in collaboration with the Rovira i Virgili University, Reus (Tarragona, Spain) and the POAL Rheumatology Institute, Barcelona (Spain) 5. Oral Mobilee supplementation improves joint mechanics function, as determined via isokinetic testing, in individual with joint discomfort. (Refer VA Page Graph) Native Collagen Type II 1. Collagen is the core structural protein present in cartilage, providing tensile strength and toughness to the tissue. 2. Some common joint conditions can activate an autoimmune response against the body’s own endogenous type II collagen, impacting joint health 3. Oral administration of Native Collagen Type II helps to maintain joint health through a mechanism of action called Oral Tolerance, at a low dose of 40 mg/day. which consists of a diminished immune response to a previously fed antigen. 4. This immune-mediated mechanism helps to regulate the body’s response to endogenous type II collagen, reducing its degradation and supporting healthy joints MOA – Native collagen type 2 1. Oral Tolerance comprises the following stages: 2. Native (undenatured) type II collagen reaches the intestine 3. It interacts with the Peyer’s patches in the intestine, which are responsible for immune surveillance 4. It turns off the immune response against endogenous type II collagen 5. It reduces collagen degradation in the joint, supporting joint health