Title 10 NOV FCPS I Recalls ✅

1 A 30-week pregnant woman is diagnosed with overt hypothyroidism. What is the drug of choice for treatment? Correct Answer: Levothyroxine Explanation: Levothyroxine is the first-line treatment for hypothyroidism in pregnancy. It is a synthetic T4 that is peripherally converted to T3, the active form. In pregnancy, thyroid hormone demand increases, especially due to elevated estrogen levels increasing thyroxine-binding globulin. Therefore, levothyroxine dose should be increased—either by two additional doses per week or by 25–30% of the daily dose. Liothyronine (T3) is not recommended during pregnancy, as it crosses the placenta more readily and lacks the steady physiologic replacement profile needed in gestation. Common Distractors: Liothyronine – Used only in myxedema coma; not safe in pregnancy. Propylthiouracil (PTU) – Treatment for hyperthyroidism, especially first trimester. Methimazole – Also for hyperthyroidism; not appropriate for hypothyroid cases. No treatment – Inappropriate as untreated hypothyroidism impairs fetal brain development. High-Yield Points: l Levothyroxine is safe and effective in pregnancy.
l Increase dose immediately upon confirmation of pregnancy. l Monitor TSH and FT4 monthly during early pregnancy, then again at 30 weeks. l Avoid liothyronine and antithyroid drugs in hypothyroid patients. For more high-yield resources, Solved Recall MCQs and medical preps: WhatsApp: +92 345 4152277 Visit: www.drwasimsme.com