Title 1. DRUG DEVELOPMENT PROCESS.pdf ✅

PHARMD GURU Page 2 TARGET FOR THERAPEUTIC INTERVENTIONS INCLUDE:  Receptors  Proteins  Enzymes  DNA  RNA  Ribosomal targets METHODS USED FOR TARGET IDENTIFICATION INCLUDE: TARGET VALIDATION: Before discovery of drug Disease to be treated needs to be understood, to identify the “underlying cause of the same” Study of disease mechanism Helps improper research Helps to formulate a possible tip to slow/reverse the disease progress CLASSICAL METHODS Cellular biology Molecular biology NEWER METHODS Genomics Proteomics
PHARMD GURU Page 3 In target validation, demonstration is required to prove that: a) Identified molecule target is involved in disease process. b) Binding of drug to the target produces curative effect. PROCESS INVOLVED IN VALIDATION:  It's also important to determine “druggability of target”  Druggability of target is defined as the ability of a target to bind to a drug. 2)LEAD IDENTIFICATION: In lead identification process ↓ Compounds that interact with the target protein is identified SOURCES OF COMPOUNDS INCLUDE: a) Natural products from microbes, plants (or) animals. b) Compound libraries: 1 0 screening ↓ Identifies Hits from compound libraries ↓ Hits are retested ↓ Retest is done independently of 1st assay (or) on a different day IN-VITRO PHASE IN-VIVO FACE DEFINES CLINICAL POTENTIAL OF TARGET RESULT