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Lippincott ® Illustrated Reviews: Biochemistry Eighth Edition Emine Ercikan Abali, PhD Assistant Dean for Basic Science Curriculum CUNY School of Medicine New York, New York Susan D. Cline, PhD Professor of Biochemistry Department of Biomedical Sciences Mercer University School of Medicine Macon, Georgia David S. Franklin, PhD Professor of Biochemistry & Molecular Biology Tulane University School of Medicine New Orleans, Louisiana Susan M. Viselli, PhD Professor of Biochemistry & Molecular Genetics College of Graduate Studies Midwestern University Downers Grove, Illinois
Acquisitions Editor: Lindsey Porambo Development Editor: Andrea Vosburgh Editorial Coordinator: Sean Hanrahan Editorial Assistant: Jada Davis Marketing Manager: Phyllis Hitner Senior Production Project Manager: Alicia Jackson Manager, Graphic Arts & Design: Steve Druding Manufacturing Coordinator: Margie Orzech Prepress Vendor: Aptara, Inc. 8th edition Copyright © 2022 Wolters Kluwer. Copyright © 2017 Wolters Kluwer. Copyright © 2014, 2011, 2008, 2005, 1994, 1987 Lippincott Williams & Wilkins, a Wolters Kluwer business. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at [email protected], or via our website at shop.lww.com (products and services). 9 8 7 6 5 4 3 2 1 Printed in China 978-1-975155-08-7 Library of Congress Cataloging-in-Publication Data available upon request This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based upon healthcare professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments. Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work. shop.lww.com
Dedication This edition is dedicated to those we teach and to those who taught us. Emine Ercikan Abali, PhD Susan D. Cline, PhD David S. Franklin, PhD Susan M. Viselli, PhD

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