Title (PCHS) PBS 7L - ANTIPYRETIC ACTIVITY (WITH PERMISSION).pdf ✅

PHARMACOLOGY 2 LABORATORY ANTIPYRETIC ACTIVITY
Brewer’s Yeast-Induced Pyrexia ▪Aim: ▪To study the antipyretic activity by the Brewer’s yeast-induced pyrexia model in animals.
Brewer’s Yeast-Induced Pyrexia ▪ Principle: ▪ Normally, the infected or damaged tissue initiates the enhanced formation of pro- inflammatory mediators (cytokines, such as interleukin-1ß, interleukin-α, interleukin-ß, and TNF-α), which increase the synthesis of prostaglandin E2 (PgE2 ) near hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature.
Brewer’s Yeast-Induced Pyrexia ▪Principle: ▪Brewer’s yeast induces both TNF-α and prostaglandin synthesis.