Title 3. COMBINATORIAL CHEMISTRY.pdf ✅

PHARMD GURU Page 3 COMBINATORIAL CHEMISTRY WITHIN DRUG DESIGN:  Combinatorial chemistry can impact at lead discovery.  Traditionally lead drugs were found from:  Natural products.  Synthetic custom crafted organic molecules made in small numbers.  Analogues of known actives (analogue me-toos).  High throughput screening (HTS) requires large numbers of compounds to fuel the discovery process.  As an alternative to traditional synthesis many compounds rapidly constructed was needed. TECHNIQUES USED IN THE COMBINATORIAL SYNTHESIS: THERAPEUTIC TARGET LEAD DISCOVERY LEAD OPTIMISATION DEVELOPMENT CANDIDATE DRUG COMBINATORIAL CHEMISTRY CAN IMPACT HERE. SOLID PHASE TECHNIQUE Solid Support Method. Parallel Synthesis. Mixed Combinatorial Synthesis. Mixed & split combinatorial Synthesis. SOLUTION PHASE TECHNIQUE