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4e(Ifit}G s o ffiatA sl t'ltu' DAO TAO HANI IIA NOI ri rur oANH crA NANc r.rlc xEl luytN nAr rrec u[, cniNn euv NAu zozs Ao udx: srNn noc Thdi gian ldm bdi: 60 phitt (kh6n7 ki thdi Sian phdt di) II Mn.!.j thi: 075 S6 b A. TO TRTN PHIT,U TRA LOI TRAC NGHIEM Phin I (3 di6il.T'-hi sinh trd ltri ttr cdu I ddn cdu 12. Odi va m& cdu, thi sinh chi chon m6t phrong dn. Ciu 1. Ph6t bi6u nio duoi tliy tling khi noi vC giai doan tiiip nh.an *,Ong trn cta t6 bAo? A. Ti! beo phat rin hiCu di6u khitin quri trinh phi6n md. d!ch mi hodc diiu hoi hoat d6ng gene cta tii bao. B. MOt phnn t& truyen tin li6n kilt vio m6t protein thy th6 cia t6 bAo dich hm thu th6 thay d6i hinh dpg. C. Chu6i cic phin ftng h6a sinh di6n ra trong t6 bdo tao thdnh con Ciu 5. Duoi tlny ld cric nhin tlinh khi nghi6n cfu hiQn tugng di truyan lien kiit gene vi ho6n vi gene: l. S5 nh6m gene li€n k6t bing s5 nhi6m sic thii trong tii bno lu6ng bQi cta toii. 2. Li€n k€t gene ddm bdo cho c6c tinh trang lu6n di truydn ctng nhau tao thdnl nh6m tinh trpg di truydn li6n k€t. 3. Hoan v! gene ld hiQn tugng c6c gene hrong ung trCn c{p nhi6m sic t}ri5 nrong dting d6i ch6 cho nhau. 4. Hoan vi gene ldm xuat hiQn nhi6u bi6n di t6 hqp cung cdp nguy€n liQu cho ti6n h6a vd chgn gi6ng. Cric nhfln tllnh dtng ld A. 1,2,4. B. 1,3,4. C. 1,2,3. D.2,3,4. CAu 6. Ngudi ta tii5n hdnh ph6p lai giBa hai ciy cl6u hd lan thuin chtng vti miu hoa tim vi miu hoa tring. Thti h6 Fr thu dugc toin ciy hoa tim. Cric c6y hoa tim ndy dugc dem lai voi c6c ciy hoa tring. Th6 h6 ti6p theo s€ phin ty theo tj' ll kiiu hin} ndo sau cl6y? A. 3 hoa tim : I hoa tr'ing. B. I hoa tim : I hoa tring. C. 100% hoa tim. D. 100% hoa tring. Ciu 7. D,! chuy6n vector tAi t6 hop mang gene ngo4i lai vao t6 bao dQng vit, ngusi ta thuong su dqng mQt sii phuong phrip du6i dAy: l. Bi6n nap bing xung Ciu 12. M6t h6 sinh thrii c6 tinh i5n dinh cao khi c6 d4c diiim nio du6i d6y? A. Luoi thrrc an don giin, sinh cdnh 6n dinh. B. Sii luqng loii lon vd nhiAu loii tla thgc. C. Kh6ng c6 sg c4nh tranh giiia c6c lodi. D. Chu6i thfc in c6 nhi6u mit xich. PhAn II (3 di6m). Thi sinh td loi tt cdu t ddn cdu 3. Trong m6i 1, a1, b), c), d) o mdi cdu. thi sinh chon tling hodc sai. Cau l. MOt tloan DNA cria chuQt c6 kich thudc 1600 cnp nucleotide duoc cit bing enzyme gidi han EcoRI thu duoc mOt tloan dei 1500 cip nucleotide. M6t vector plasmid c6 kich thu6c 4000 cap nucleotide c[ng tl6 duoc "it mo vdng bing enzyme EcoRI. Doan DNA sau k]ri cit aa dugc ntii thinh c6ng vao vector plasmid n6i tr6n. Tu c6c th6ng tin tr6n, m5i nhdn DQng t'it I T 16 d6ns 1 c6 l6a <- c6 Miur +tttr++{r+l Hinh I B. VITT TRTN TO GIAY THI Phf,n III (l tli6m). Thi sinh rrd loi ti cdu t cliin cdu 4. Ddi vA m6i cau, thi sinh chi t'iit kit qua. khdng trinh bdy suy luQn. Ceu 1. MOt gene d vi khuin E. coli c6 4300 c{p nucleotide. Trong il6 c6 250 cdp nucleotidc kh6ng dugc dich me (UTR). ChuSi polypeptide hoin thiQn do gene ndy quy dlnh chua bao nhi6u amino acid? Ciu 2. C6c tec nhan gay d6t bitin d6ng. vai trd quan trong trong vi6c tao ra c6c dQt bi6n gene. Trong d6, 5BU (5 bromouracil) gAy ra Ciu 3. HQi chimg Down d ngudi gdy ra do du thua mOt NST s5 21. Nguy6n nhAn phnt sinh hQi chung ndy thuong li do sg r6i loan phin ly NST trong quri trinh ginm ph6n tao giao tu cr)a ngudi me. C6ng thric NST cia ngudi n[ gidi binh thudng ln 46, XX. Hny vi6t cong thrlrc NST cta m6t nam gioi mic hdi chung Down do du thira mdt NST s6 2 l. Ciu 4. Hign tuong ho6n_vi gene xiy ra d ki clAu cta giai doqn giim ph6n l. Thdi ttitim ndy di6n 3 sy ti6p hgp gi[a cric nhi6m sic th€ k6p trong cflp NST tuong . ;.eooi co E :c. 5;' so rE -tr f! 20 :o oa 10 t civ B C6v 0 20 40 60 80 Nbng dO cornOi beo (mt corlt) Ilinh 2 100 Trang4l4 - Ma dC thi 075 )

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