Title INTEGRATED SYSTEMS (1).pdf ✅

Pulse Medical Institute - Integrated Hematology - Target 175 By Dr KK - Dr Roundz MEGA REVISION PROGRAMME 269 Leucopoiesis: Lymphoid Lineage: • Pluripotent Hematopoietic Stem Cell (PHSC) → Lymphoid Stem Cell → Lymphoblast → Lymphocyte Myeloid Lineage: Granulocytes: • PHSC → CFU-GM → Myeloblast → Promyelocyte → Myelocyte → Metamyelocyte • Neutrophil lineage → Neutrophil • Eosinophil lineage → Eosinophil • Basophil lineage → Basophil Monocyte/Macrophage: • PHSC → CFU-GM → Monoblast → Promonocyte → Monocyte • Monocyte → Macrophage (in tissue) Regulation: Regulator Function Drug Form G-CSF (Granulocyte Colony-Stimulating Factor) Stimulates granulocyte production Filgrastim GM-CSF (Granulocyte-Monocyte CSF) Stimulates granulocyte & monocyte lines Sargramostim IL-5 Promotes eosinophil development — IL-3 & IL-4 Promote basophil development — Thrombopoiesis: • Stem cell origin: PHSC (Pluripotent Hematopoietic Stem Cell) • Differentiates into: Megakaryocyte progenitor (CFU-Meg) • Matures into: Megakaryocyte • Fragmentation produces: Platelets • Regulators: • Thrombopoietin (Drug: Eltrombopag) • IL-11 (Drug: Oprelvekin) RBC: • Normal size of an RBC 7-15 μm • To identify & the RBCs are macrocytic, microcytic or normal, the size of an RBC is compared with the nucleus of lymphocyte • Life span of RBC 120 days • RBCs originate from Haemopoietic Stem Cells (HSC) which develop into the Common Myeloid Progenitor (CMP) cells • HSC→ CMP→ Proerythroblast→ Early normoblast (basophile normoblast)→ Intermediate normoblast (polychromatic normoblast)→ Late normoblast (orthochromatic normoblast)→ Reticulocyte → RBC Page 269