Title 8 Introduction To Hydrocephalus.pdf ✅

3 OLDER CHILDREN with CLOSED FONTANELLE : Clinical signs of intra cranial hypertension +, without progressive head enlargement . Pathology : · Rate of CSF absorption-driven by ICP. · Arachnoid granulations provide resistance Intracranial veuons sinus pressure to CSF outflow · Laplace's law : drives the pressure within the ventricles . 2 X wall thickness X wall tension P = Radius PC'r · Pressure required to overcome the tension in surrounding cerebral mantle is less in enlarged ventrides , than it is in smaller ventrides . · Sequelae , if untreated : Irreversible alldamage dueto: 1 Gliosis 3 Metabolic impairment 2) Neuro inflammation Altered BBB transport 3) Demyelination 8) Cell death 4) Axonal degeneration 5) Altered neuronal connectivity