Title Part 3 Regulation of Kidney Function and Disorders.pdf ✅

➢ The functioning of the kidneys is efficiently monitored and regulated by hormonal feedback mechanisms involving I. Hypothalamus II. Juxtaglomerular apparatus (JGA) III. Heart ➢ Osmoreceptors in the body are activated by changes in o Blood volume o Body fluid volume o Ionic concentration
➢ When body fluid level decreases, the osmoreceptors stimulate the hypothalamus to release antidiuretic hormone (ADH or vasopressin). ➢ It stimulates water reabsorption from DCT & collecting duct.Thus, ADH prevents diuresis and increases body fluid volume. ➢ Increase in fluid volume switches off the osmoreceptors and suppresses the ADH release to complete the feedback.
➢ ADH can also affect the kidney function by its constrictory effects on blood vessels. ➢ This causes an increase in blood pressure. An increase in blood pressure can increase the glomerular blood flow and thereby the GFR.