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Content text (PCHS) PHARCHEM 5L - ANTIDOTAL THERAPIES (WITH PERMISSION).pdf

ANTIDOTAL THERAPIES PHARMACEUTICAL TOXICOLOGY LABORATORY
GLYCOPYRROLATE  Competitive inhibition of ACh binding at muscarinic receptors.
BARBITURATES  Enhance GABA effects by ↑ duration of GABAA - mediated chloride channel opening →↑intracellular Cl- → membrane hyperpolarization and ↓ neuronal electrical activity
BARBITURATES  Generally used as second or third line agents for treating toxin-induced seizures and ethanol withdrawal refractory to benzodiazepines.

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