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CHROMATOGRAPHY PHARMACEUTICAL ANALYSIS 2
CHROMATOGRAPHY. A process in which a solution of a mixture containing inert materials, drug principles and impurities is separated into its components while moving through a bed of fixed porous solid having different and reversible affinities for the substances being separated.
CHROMATOGRAPHY. The separation of substances comes about because each component of the mixture possesses a different mobility by reason of differences in adsorption, partition solubility, vapor pressure, molecular size or ionic charge.
CHROMATOGRAPHY. It is particularly useful as a means of separating and purifying complex and closely related chemical substances which are difficult if not impossible to separate by chemical methods based on differences in solubility and volatility.