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Content text (PCHS) PHARCHEM 5 - MECHANISM OF TOXICITY (PART 2) - WITH PERMISSION.pdf

 MECHANISM OF TOXICITY (Part 2) Pharmaceutical Toxicology Laboratory
 INSULIN ▪ Deliberate self-administered insulin overdose causes profound and prolonged hypoglycemia that may result in life- threatening seizures, coma and permanent neurological injury.
 INSULIN ▪ Mechanism of Toxicity: ▪ Insulin is released from the beta-pancreatic islet cells at a low basal rate, which increases in response to various stimuli.
 INSULIN ▪ Mechanism of Toxicity: ▪ Exogenous insulin is used for the treatment of type 1 and type 2 diabetes mellitus, severe hyperkalemia and calcium channel blocker overdose.

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