Title 7.1 Carcinoma de Merkel - Dr. José Luis Manzano.pdf ✅

Tumores Cutáneos No melanoma CARCINOMA MERKEL J.L.Manzano H Germans Trias i Pujol ICO-Badalona Alacalá de Henares 23 de noviembre 2024
Incidence and Survival of Merkel cell carcinoma S.T. Mohsen et al, Br J Dermatol 2024; 190:811-824 Incidence Survival
Risk Factors MCC – Older age: Mean age of MCC diagnosis is ~75 years – Male sex: Incidence in men vs women = 0.4–2.5 vs 0.18–0.9 per 100,000 PPY – UV exposure: ~95% of diagnosed cases are in the white population – Other malignancies: Increased risk in individuals with multiple myeloma, chronic lymphocytic leukemia, and malignant melanoma – Immunosuppression: Increased risk with organ transplant, HIV infection, and use of immunosuppressive medication – MCPyV infection (80% of MCC in Europe) Gauci M.L. et al, EJC 2022
Pathogenesis MCC Gog G. et al, Oncotarget 2018